Harrington classification

Metastatic spine tumor description

Class I

No significant neurologic involvement

Class II

Involvement of bone without collapse or instability

Class III

Major neurologic impairment (sensory or motor) without significant involvement of bone

Class IV

Vertebral collapse with pain due to mechanical causes or instability but without significant neurologic compromise

Class V

Vertebral collapse with pain due to mechanical causes or instability combined with major neurologic impairment

Reference

van der Linden YM, Dijkstra SPDS, Vonk EJA, Marijnen CAM, Leer JWH, Dutch Bone Metastasis Study Group. Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer. 2005 Jan. 15;103(2):320-328.

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